Geoffrey Kondogbia and ex Tottenham striker Dimitar Berbatov got the goals to give Arsene Wenger's former club the advantage going into the second leg.
Alex Oxlade-Chamberlain scored a late goal for the Gunners to increase raise hopes they can overcome the Ligue 1 club in the tie, but a late strike from Yannick Ferreira-Carrasco restored the two-goal margin.
Meanwhile, Hakan Calhanoglu scored in the second half to give Bayer Leverkusen a 1-0 home win over last year's finalists Atletico Madrid.
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